| Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CSF2RA; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; MGC3848; MGC4838 | ||||||||||
| External IDs | OMIM: 425000 MGI: 1339754 HomoloGene: 48406 GeneCards: CSF2RA Gene | ||||||||||
|
|||||||||||
| RNA expression pattern | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 1438 | 12982 | |||||||||
| Ensembl | ENSG00000198223 | ENSMUSG00000059326 | |||||||||
| UniProt | P15509 | Q00941 | |||||||||
| RefSeq (mRNA) | NM_001161529.1 | NM_009970.2 | |||||||||
| RefSeq (protein) | NP_001155001.1 | NP_034100.2 | |||||||||
| Location (UCSC) | Chr X: 1.39 – 1.43 Mb |
Chr 19: 61.3 – 61.3 Mb |
|||||||||
| PubMed search | [1] | [2] | |||||||||
The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[1]
It is associated with Surfactant metabolism dysfunction type 4.
Contents |
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[3]
Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.[4]
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||